Illuminating somatostatin analog action at neuroendocrine tumor receptors
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چکیده
منابع مشابه
Somatostatin Receptors in the Diagnosis and Therapy of Neuroendocrine Tumor.
The expression of somatostatin receptors in neuroendocrine tumors has facilitated the diagnosis and surgical treatment of patients with these tumors. After injection of a radiolabeled long-acting somatostatin analog, (111)In-octreotide, scintigraphic tumor imaging can ben performed as well as intraoperative tumor localization. During localization studies very high (111)In concentration values w...
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Five somatostatin receptor (sst) subtype genes, sst(1), sst(2), sst(3), sst(4) and sst(5), have been cloned and characterised. The five sst subtypes all bind natural somatostatin-14 and somatostatin-28 with high affinity. Endocrine pancreatic and endocrine digestive tract tumours also express multiple sst subtypes, but sst(2) predominance is generally found. However, there is considerable varia...
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2013
ISSN: 0165-6147
DOI: 10.1016/j.tips.2013.10.001